Individuals living with chronic health conditions are at increased risk for a range of secondary complicatons such as Depression, chronic pain, and cognitive dysfunction. Nonetheless, many individuals with chronic conditions also thrive, demonstrating resilience and psychological well-being. This lecture will provide an overview of the effects of chronic health conditions on the health, well-being, and resilience of the affected individuals. It will also decribe several innovative interventions for promoting resilience and well-being in the context of chronic conditions.